Impact of quality and safety product on competitiveness

This work should indicate how an integrated approach to continuous improvement of quality and safety of products affecting the competitiveness goals as product and company. The impact of Quality Management System (QMS) and compatibility with the requirements of the New Approach Directives (the CE mark) we conducted in three directions. First we developed a model that includes all the essential steps. By using the modeling method of the complex dynamic system, three macro variables are determined in the model. Each of the macro variables has its structure, variables in the in order to research the practical impact of QMS and CE mark on the competitiveness of enterprises in Serbia, we created a questionnaire on the basis of established models. On the results we apply methods of statistical analysis. In order to further research mentioned impacts on the competitiveness of products in Serbia, we have created a simulation software. This paper presents some of the results that have a dominant impact on competitiveness. From all this we can conclude that the implementation of QMS and CE creates a positive image of the product on the market, and enables the growth of profits and the competitiveness of organization

Ubikvitinom posredovana degradacija unutarćelijskih proteina

Eukaryotic cells, from yeast to human, contain some 6000 to 30000 protein-encoding genes and at least as many proteins. While much attention and research had been devoted to how proteins are synthesized, the reverse process, i.e. how proteins are degraded, long received little attention. The Nobel Prize in Chemistry for 2004 is shared between three scientists: Aaron Ciechanover, Avram Hershko and Irwin Rose who discovered ubiquitin-mediated proteolysis. Numerous cellular processes regulated by ubiquitin-mediated proteolysis include the immune response, cell cycle, DNA repair and transcription and protein quality control

Ubikvitinom posredovana degradacija unutarćelijskih proteina

Eukaryotic cells, from yeast to human, contain some 6000 to 30000 protein-encoding genes and at least as many proteins. While much attention and research had been devoted to how proteins are synthesized, the reverse process, i.e. how proteins are degraded, long received little attention. The Nobel Prize in Chemistry for 2004 is shared between three scientists: Aaron Ciechanover, Avram Hershko and Irwin Rose who discovered ubiquitin-mediated proteolysis. Numerous cellular processes regulated by ubiquitin-mediated proteolysis include the immune response, cell cycle, DNA repair and transcription and protein quality control

Design Aspects of Hip Implant Made of Ti-6Al-4V Extra Low Interstitials Alloy

The main concerns in design of hip implants are fracture and fatigue related issues. In this paper, reverse engineering is used to redesign a hip implant produced by precision casting, using Ti6Al4V Extra Low Interstitials (ELI) alloy. As the most critical part, hip neck has been in the focus of this analysis, keeping in mind that the lower the thickness is, the higher the movement of joint may be, but affecting its structural integrity at the same time. Thus, 5 different models are created with different neck thickness and analyzed by using the Finite Element Method (FEM) for stress-strain calculation and extended FEM (XFEM) for fatigue crack growth

Surface modification of laser welded nimonic 263 sheets

Laser surface treatment is both a thermomechanical and mechanical process, based on the ability of a high energy laser pulse to generate shock waves and plastic deformation in metallic materials. Laser welding is a high energy density process with many advantages such as narrow heat affected zone, lower heat input and lower heat/energy distortion compared to conventional welding processes. In this paper, Nimonic 263 alloy sheets are laser welded by Nd:YAG laser using different laser processing parameters. The microstructure, surface roughness and mechanical properties are investigated. Welded joints are mechanically treated by laser in order to improve the surface and mechanical characteristics. Mechanical characteristics are determined by tensile test, and fractures and laser treated weld surfaces are observed by scanning and optical microscopy. Surface topography is analysed by optical profilometry and micro hardness is measured by Vickers method

Surface modification of laser welded nimonic 263 sheets

Laser surface treatment is both a thermomechanical and mechanical process, based on the ability of a high energy laser pulse to generate shock waves and plastic deformation in metallic materials. Laser welding is a high energy density process with many advantages such as narrow heat affected zone, lower heat input and lower heat/energy distortion compared to conventional welding processes. In this paper, Nimonic 263 alloy sheets are laser welded by Nd:YAG laser using different laser processing parameters. The microstructure, surface roughness and mechanical properties are investigated. Welded joints are mechanically treated by laser in order to improve the surface and mechanical characteristics. Mechanical characteristics are determined by tensile test, and fractures and laser treated weld surfaces are observed by scanning and optical microscopy. Surface topography is analysed by optical profilometry and micro hardness is measured by Vickers method

Design Aspects of Hip Implant Made of Ti-6Al-4V Extra Low Interstitials Alloy

The main concerns in design of hip implants are fracture and fatigue related issues. In this paper, reverse engineering is used to redesign a hip implant produced by precision casting, using Ti6Al4V Extra Low Interstitials (ELI) alloy. As the most critical part, hip neck has been in the focus of this analysis, keeping in mind that the lower the thickness is, the higher the movement of joint may be, but affecting its structural integrity at the same time. Thus, 5 different models are created with different neck thickness and analyzed by using the Finite Element Method (FEM) for stress-strain calculation and extended FEM (XFEM) for fatigue crack growth

Integrity assessment of reverse engineered ti-6al-4v eli total hip replacement implant

Total hip replacement implants are used as an artificial replacement for disfunctional hips in order to sustain joint movement. Chosen material and design of total hip replacement are the most influential factors for artificial joint utilization. Selected total hip replacement is obtained by precision casting method, made from Ti6Al4V ELI (Extra Low Interstitials) alloy. In order to acquire a geometrical model of chosen implant, the 3D scanner is used and an obtained point cloud (PC), then exploited for reverse engineering to a CAD model. The neck thickness of implant affects angle of movement of the joint and structural integrity. Reducing the thickness of the neck section results in higher movement of the joint, but inversely affects its structural integrity. The 3D scanned implant has a neck thickness of 14.6 mm, and data from literature suggest that the best movement angle is for 9 mm thickness of the implant. In order to redesign the available implant, five different models with a neck thickness between 9 and 14.6 mm are made. Obtained results show the thickness effects the stress distribution in a critical area

Ispitivanje stabilnosti vakcine kućne prašine za sublingvalnu imunoterapiju

Allergen-specific immunotherapy with house dust mite (HDM) allergen extracts can effectively alleviate the symptoms of allergic rhinitis and asthma. The efficacy of the immunotherapeutic treatment is highly dependent on the quality of house dust mite vaccines. This study was performed to assess the stability of house dust mite allergen vaccines prepared for sublingual immunotherapy. Lyophilized Dermatophagoides pteronyssinus (Dpt) mite bodies were the starting material for the production of sublingual vaccines in four therapeutic concentrations. The stability of the extract for vaccine production, which was stored below 4 °C for one month, showed consistence in the protein profile in SDS PAGE. ELISA-inhibition showed that the potencies of Dpt vaccines during a 12 month period were to 65-80 % preserved at all analyzed therapeutic concentrations. This study showed that glycerinated Dpt vaccines stored at 4°C preserved their IgE-binding potential during a 12 month period, implying their suitability for sublingual immunotherapeutic treatment of HDM allergy.Alergen-specifična imunoterapija predstavlja postupak koji može da promeni tok bolesti kod alergijskog rinitisa i astme. Kvalitet vakcine pripremljene od kućnih grinja značajno utiče na efikasnost imunoterapeutskog tretmana. Ispitivanje je imalo za cilj procenu stabilnosti vakcine kućnih grinja namenjene za sublingvalnu imunoterapiju. Telo liofilozovanih Dermatophagoides pteronyssinus grinja (Dpt-grinja) upotrebljeno je kao polazni materijal za proizvodnju sublingvalne vakcine u 4 različita terapeutska razblaženja. Potentnost Dpt vakcina praćena ELISA-inhibicijom u 4 terapeutska razblaženja, nakon 12 meseci zadržan je u svim razblaženjima u opsegu 65-80%. Ispitivanje je pokazalo da glicerolom stabilizovane Dpt vakcine za subligvalnu imunoterapiju, uz čuvanje na 4°C zadržavaju alergeni potencijal ( gt 65%) nakon 12 meseci od njihove pripreme, i kao takve mogu se koristiti za tretman alergije na kućne grinje